The Multiple Myeloma Market represents a dynamic and evolving segment of oncology, addressing a complex hematological malignancy characterized by abnormal plasma cell proliferation in the bone marrow. This market encompasses an extensive pipeline of innovative therapies and a range of marketed drugs, highlighting the intense focus on precision medicine, targeted therapies, and patient-centric treatment options.
Disruptive Impact and Opportunities:
The multiple myeloma landscape is undergoing a disruptive transformation, driven by advancements in novel treatment modalities such as CAR-T cell therapies, bispecific antibodies, and next-generation immunomodulatory drugs. These innovations offer unprecedented opportunities for improving patient outcomes, streamlining treatment pathways, enhancing safety profiles, and unlocking a substantial unmet medical need. Emerging drugs like Venetoclax, Ciltacabtagene Autoleucel, REGN5458, and Iberdomide exemplify the commitment to addressing disease progression and resistance, while marketed therapies such as Darzalex, Sarclisa, and Abecma continue to redefine standards of care.
Venetoclax
Ciltacabtagene Autoleucel
REGN5458
Iberdomide
Darzalex
Sarclisa
Abecma
Key Companies:
Sanofi
Janssen Biotech
Bristol-Myers Squibb
Karyopharm Therapeutics
GlaxoSmithKline
Therapies
Immunomodulatory Drugs (IMiDs)
Lenalidomide
Pomalidomide
Thalidomide
Proteasome Inhibitors
Bortezomib
Carfilzomib
Ixazomib
Monoclonal Antibodies
Daratumumab
Isatuximab
Elotuzumab
Histone Deacetylase (HDAC) Inhibitors
Panobinostat
Antibody-Drug Conjugates (ADCs)
Belantamab Mafodotin
Bispecific T-Cell Engagers (BiTEs)
Teclistamab
CAR-T Cell Therapies
Idecabtagene Vicleucel
Ciltacabtagene Autoleucel
Alkylating Agents
Melphalan
Cyclophosphamide
Corticosteroids
Dexamethasone
Prednisone
· Oral
Tablets
Capsules
· Injectable
Intravenous (IV)
Subcutaneous (SC)
What’s in It for You?
Comprehensive insights into emerging therapies, including CAR-T and bispecific antibody technologies.
An analysis of existing marketed drugs and their competitive positioning in the treatment paradigm.
Opportunities to identify unmet needs, market gaps, and potential partnerships.
A deep dive into key players' strategies and their impact on innovation and commercialization.
Data-driven perspectives to aid portfolio optimization, market entry planning, and long-term investment decisions.
Multiple Myeloma Market Analysis (Market Size & CAGR, Epidemiology, Marketed Therapies, Emerging Drugs, Clinical Trials, Key Approvals & Anticipated Loss of Exclusivity, Opportunities, Unmet Needs, Company Profiles)
1 Multiple Myeloma Market - Executive Summary
1.1. Introduction
1.2. Objectives
1.3. Key Findings
1.3.1. Market Size 2022 & 2032: By Key Country (10MM)
1.3.2. Global Market Size 2022 & 2032: By Key Segment
1.3.3. Key Investments & Startup Analysis
1.4. Research Methodology
2 Understanding the Disease
2.1. Disease Overview
2.2. Classification
2.3. Signs and Symptoms
2.4. Risk Factors
2.5. Causes
2.6. Disease Biology & Digital Innovations
2.7. Stages & Staging System
2.8. Diagnostic Algorithm
2.9. Current Treatment Practices & Algorithm
2.10. Current Standard of Care and Treatment Gaps
2.11. Patient Demographics and Treatment Pathways
3 Guidelines
4 Unmet Needs
5 Epidemiology and Patient Population
5.1. Epidemiology Key Findings
5.2. Assumptions and Rationale: 10MM
5.3. Epidemiology Scenario: 10MM
5.4. U.S. Epidemiology Scenario
5.5. EU-5 Epidemiology
5.5.1. U.K. Epidemiology Scenario
5.5.2. Germany Epidemiology Scenario
5.5.3. France Epidemiology Scenario
5.5.4. Italy Epidemiology Scenario
5.5.5. Spain Epidemiology Scenario
5.6. Japan Epidemiology Scenario
5.7. China Epidemiology Scenario
5.8. Australia Epidemiology Scenario
5.9. India Epidemiology Scenario
6 Real-world Data & Real-world Evidence
7 Drug Development Landscape
7.1. Existing Key Drug Candidate Profiles/ Marketed Therapies
7.1.1. Blenrep (Belantamab Mafodotin /GSK2857916)
7.1.1.1. Product Description
7.1.1.2. Regulatory Milestones
7.1.1.3. Other Developmental Activities
7.1.1.4. Pivotal Clinical Trials
7.1.1.5. Ongoing Current Pipeline Activity
7.1.2. Abecma (Idecabtagene vicleucel/bb2121/ ide-cel)
7.1.2.1. Product Description
7.1.2.2. Regulatory Milestones
7.1.2.3. Other Developmental Activities
7.1.2.4. Pivotal Clinical Trials
7.1.2.5. Ongoing Current Pipeline Activity
7.1.3. Pepaxto (melflufen/ melphalan flufenamide)
7.1.3.1. Product Description
7.1.3.2. Regulatory Milestones
7.1.3.3. Other Developmental Activities
7.1.3.4. Pivotal Clinical Trials
7.1.3.5. Ongoing Current Pipeline Activity
7.1.4. Sarclisa (Isatuximab)
7.1.4.1. Product Description
7.1.4.2. Regulatory Milestones
7.1.4.3. Other Developmental Activities
7.1.4.4. Pivotal Clinical Trials
7.1.4.5. Ongoing Current Pipeline Activity
7.1.5. Xpovio (Selinexor)
7.1.5.1. Product Description
7.1.5.2. Regulatory Milestones
7.1.5.3. Other Developmental Activities
7.1.5.4. Pivotal Clinical Trials
7.1.5.5. Ongoing Current Pipeline Activity
7.2. Competitive Analysis and Differentiation
7.3. Overview of Similar/Competing Drugs in Clinical Trials
7.4. Future Trends and Emerging Drugs
7.4.1. Venetoclax (ABT-199)
7.4.1.1. Product Description
7.4.1.2. Clinical Development
7.4.1.3. Safety and Efficacy
7.4.2. Ciltacabtagene Autoleucel (cilta-cel/ JNJ-4528/ JNJ-68284528/ LCAR-B38M)
7.4.2.1. Product Description
7.4.2.2. Clinical Development
7.4.2.3. Safety and Efficacy
7.4.3. REGN5458
7.4.3.1. Product Description
7.4.3.2. Clinical Development
7.4.3.3. Safety and Efficacy
7.4.4. Iberdomide (CC-220)
7.4.4.1. Product Description
7.4.4.2. Clinical Development
7.4.4.3. Safety and Efficacy
8 Regulatory Strategy and Potential Challenges
8.1. Regulatory Pathways in Key Markets
8.2. Anticipated Regulatory Hurdles and Mitigation Strategies
8.3. Case Studies in Oncology Drug Regulation
8.4. Impact of Potential Changes to Regulatory Framework
9 Commercial Landscape
9.1. Market Size & Growth Rates
9.2. Key Approvals & Anticipated Loss of Exclusivity
9.3. PESTLE & Porter’s Five Forces Analysis
9.4. Market Shares, Positioning/Ranking
9.5. Market Drivers
9.6. Identification of Threats
9.7. Digital Evolution in Commercialization
10 Market Segmentation
10.1. Market by Type
10.1.1. Smouldering Multiple Myeloma
10.1.2. Active Multiple Myeloma
11 Pricing, Reimbursement, and Access
11.1. Competitive Pricing Analysis
11.2. Reimbursement Landscape and Challenges
11.3. Strategies for Market Access and Equity
11.4. Patient Spending/Expenditure Analysis
12 Future Trends, Disruptions, and Opportunities
12.1. Analysis of Emerging Trends
12.2. Technological Impact
12.3. Impact of Potential Market Disruptors
12.4. Opportunities for Future Development and Expansion
12.5. Considerations for Investment Opportunities
13 Global Market Dynamics
13.1. Regional Regulatory Disparities
13.2. Cross-Border Partnership Strategies
13.3. Global Supply Chain Dynamics
13.4. Case Studies: Success and Failure in Global Markets
13.5. Strategies for Global Expansion and Localization
14 Company Profiles
14.1. Sanofi
14.2. Karyopharm Therapeutics
14.3. AbbVie
14.4. Takeda Pharmaceutical
14.5. Bristol-Myers Squibb
14.6. RAPA Therapeutics
14.7. Pfizer
14.8. AstraZeneca
14.9. Johnson & Johnson
14.10. Merck
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