Prostate cancer is a type of cancer that occurs in the prostate gland, a small walnut-shaped gland in males that produces seminal fluid, which nourishes and transports sperm. It is one of the most common types of cancer in men. In the United States, prostate cancer is the second most frequent cancer among males, trailing only skin cancer. Prostate cancer is highly treatable if found early. The risk of prostate cancer rises with age. Other risk factors include obesity, high-fat diets, and a family history of prostate cancer. African-American men have a 70% higher chance of having prostate cancer than non-Hispanic Caucasians.
AstraZeneca Plc is a holding corporation that focuses on pharmaceutical research, development, and manufacturing. Its pipeline includes treatments for oncology, cardiovascular, renal, metabolic, and respiratory diseases. The company was created on June 17, 1992, and is based in Cambridge, United Kingdom. Lynparza (Olaparib) is approved in 96 countries for homologous recombination repair (HRR) gene-mutated mCRPC (BRCAm only in certain countries) and in 59 countries with abiraterone for 1st-line mCRPC.
Novartis AG is a holding corporation that develops, manufactures, and markets healthcare goods. It operates in three segments: Innovative Medicines, Sandoz, and Corporate. Novartis Oncology and Novartis Pharmaceuticals are the two business areas that comprise the Innovative Medicines segment, which conducts research, development, manufacturing, distribution, and sales of patented pharmaceutical products. Sandoz develops, manufactures, and markets finished dosage form medications, as well as intermediate goods containing active pharmaceutical components. The Corporate section covers group management and central services. The company was created on February 29, 1996, and is based in Basel, Switzerland. Pluvicto (USD 1.0 billion, +262%, +261% cc) saw continued sales growth in the US. Pluvicto is the first and only radioligand therapy approved by the FDA for the treatment of adult patients with progressive, PSMA-positive metastatic castration-resistant prostate cancer, who have already been treated with other anticancer treatments (ARPI and taxane-based chemotherapy).
Pfizer, one of the world's biggest pharmaceutical corporations, was founded over 170 years ago. They concentrate in expert therapy across six product portfolios: vaccines, oncology, internal medicine, rare diseases, inflammation and immunology, and hospitals. Charles Pfizer Sr. and Charles Erhart formed the corporation in 1849, and its headquarters are in New York, NY. Ibrance sale declines primarily driven by lower demand globally due to competitive pressure, lower clinical trial purchases internationally, and planned price decreases in certain international developed markets. Talzenna (talazoparib) in combination with Xtandi (enzalutamide) for adult patients with homologous recombination repair (HRR) gene mutated mCRPC was approved in June 2023 in US, in January 2024 in EU and Japan.
Merck & Co., Inc. is a global health care corporation that provides health solutions through prescription medications, vaccines, biologic therapies, animal health, and consumer care products, which it offers both directly and through joint ventures. The Company's operations include pharmaceuticals, animal health, and consumer care. In 1668, Jacob Friedrich Merck established the corporation as a bought drug store in Darmstadt, Germany. Merck & Co. was established as a subsidiary in the United States in 1891. In December 2022, EC approved Lynparza in combination with abiraterone and prednisone or prednisolone for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) in whom chemotherapy is not clinically indicated.
Sanofi is a global leader in healthcare and pharmaceuticals headquartered in Paris, France. It operates in three business segments: pharmaceuticals, consumer healthcare, and vaccines. The Pharmaceuticals business includes the commercial operations of the following worldwide franchises: specialized care, diabetes and cardiovascular, established prescription medicines and generics, and R&D and production activities. The Consumer Healthcare sector include the commercial operations for its Consumer Healthcare goods. The Vaccines section includes Sanofi Pasteur's commercial operations. JEVTANA posted net sales of €320 million in 2023 (-14.8% CER), reflecting the launch of generics in Europe in March 2021 and competitive pressures in the United States. JEVTANA was approved in combination with prednisone for the treatment of patients with metastatic castration resistant prostate cancer previously treated with a docetaxel containing treatment regimen. JEVTANA was granted marketing authorization by the FDA in June 2010, by the EC in March 2011, and in Japan in July 2014.
Bayer AG develops, manufactures, and distributes goods in health care, nutrition, and high-tech materials. It operates in five segments: pharmaceuticals, consumer health, crop science, animal health, and Covestro. Bayer AG manufactures and markets medicinal and agricultural goods. Aspirin, antibiotics, anti-infectives, cardiovascular, oncology, central nervous system pharmaceuticals, over-the-counter medications, diagnostics, animal health products, crop protection goods, plastics, and polyurethanes are among the products manufactured by the company. Friedrich Bayer and Johann Friedrich Westkott formed the corporation on August 1, 1863, and its headquarters are in Leverkusen, Germany. In February 2023, Bayer received approval in Japan for an additional indication for cancer drug Nubeqa™ in patients with metastatic hormone-sensitive prostate cancer (mHSPC). Approval for this label extension was then also granted by the European Commission and the Chinese regulatory authorities in March 2023.
Johnson & Johnson is a holding corporation, which participates in the research and development, manufacture and sale of products in the health care area. It operates in three segments: consumer, pharmaceuticals, and medical devices. The Consumer section covers products used in the baby care, oral care, beauty, over-the-counter pharmaceutical, women's health, and wound care industries. The Pharmaceutical section specializes in therapeutic areas such as immunology, infectious illnesses and vaccines, neurology, oncology, cardiovascular and metabolic, and pulmonary hypertension. The Medical Devices sector provides devices for orthopedic, surgical, cardiovascular, diabetic care, and eye health applications. Robert Wood Johnson I, James Wood Johnson, and Edward Mead Johnson Sr. formed the corporation in 1886, and its headquarters are in New Brunswick, New Jersey. ERLEADA (apalutamide), a next-generation androgen receptor inhibitor for the treatment of patients with prostate cancer. Growth of ERLEADA (apalutamide) was due to continued share gains and market growth in Metastatic Castration Resistant Prostate Cancer.
Astellas Pharma, Inc. manufactures, imports, and exports pharmaceutical goods. Its products target therapeutic areas such as transplantation, immunology, infectious illnesses, urology, oncology, neurology, diabetic complications, and metabolic diseases. The company's global brands include Prograf, Vesicare, Protopic, Harnal, and Funguard. Kenji Yamanouchi created the company in April 1923, and it is headquartered in Tokyo, Japan. In September 2012, Astellas launched XTANDI Target disease: Prostate Cancer Entered cell therapy platform.
AbbVie, Inc. is a research-based biopharmaceutical firm that develops and sells pharmaceutical products. It specializes in treating chronic autoimmune diseases in rheumatology, gastroenterology, and dermatology; oncology, including blood cancers; virology, including hepatitis C virus (HCV) and human immunodeficiency virus (HIV); neurological disorders, such as Parkinson's disease; metabolic diseases, including thyroid disease and cystic fibrosis complications; endometriosis pain; and other serious health conditions. The company was created on October 19, 2011, and is based in North Chicago, Illinois. Lupron (leuprolide acetate), which is also marketed as Lucrin and Lupron Depot, is a product for the palliative treatment of advanced prostate cancer.
TOLMAR Inc. offers contract pharmaceutical R&D, production, and packaging services. The company develops and manufactures both innovative and generic pharmaceutical products, with an emphasis on the therapeutic areas of dentistry, dermatology, and oncology. TOLMAR operates in Illinois and Colorado. In May 2016, TOLMAR Pharmaceuticals, Inc., announced that approval has been received from FDA for a label update for ELIGARD®, indicated for the palliative treatment of advanced prostate cancer.
Author: Pranabesh Dutta
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